Abstract Search

ea0026p191 | Pituitary | ECE2011

The treatment with dopamine agonists are not associated with increased prevalence of cardiac-valve regurgitation in patients with prolactinomas and acromegalia

Puma M , Lecumberri B , Fernandez A , Dominguez F , Martin M , Yanguela M , Pallardo L , Alvarez C

Background: Dopamine agonists are first-line agents for the treatment of prolactinomas and sometimes are used in patients with acromegalia. There is evidence that these drugs, especially cabergoline, are associated with an increased risk of new cardiac valve regurgitation in patients treated for Parkinsons disease.Objective: Our objective was to evaluate the prevalence of cardiac valve regurgitation in patients with prolactinomas and acromegalia tr...

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ea0017p24 | (1) | BSPED2008

Characterisation of seven novel 11β-hydroxylase (CYP11B1) gene mutations: three severe and four mild mutations

Parajes S , Loidi L , Rumsby G , Kirk J , Cole T , Conway G , Quinkler M , Dominguez F , Arlt W , Krone N

Congenital adrenal hyperplasia (CAH) is one of the most common autosomal recessive disorders. About 58% of cases are caused by the deficiency of steroid 11β-hydroxylase (CYP11B1) due to mutations in CYP11B1 gene. CYP11B1-inactivating mutations can be found without particular hot-spot spread over the entire gene. A good phenotype-genotype correlation exists for the patients suffering from 11β-hydroxylase deficiency (11OHD). The prediction of diseas...

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Endocrine Abstracts

The treatment with dopamine agonists are not associated with increased prevalence of cardiac-valve regurgitation in patients with prolactinomas and acromegalia

Characterisation of seven novel 11β-hydroxylase (CYP11B1) gene mutations: three severe and four mild mutations

BiosciAbstracts